It is meaningful to assess the risk of cancer incidence among patients with precancerous colorectal lesions. Comparing the within-sample relative expression orderings (REOs) of colorectal cancer patients measured by multiple platforms with that of normal colorectal tissues, a qualitative transcriptional signature consisting of 1,840 gene pairs was identified in the training data. Within an evaluation dataset of 16 active and 18 inactive (remissive) ulcerative colitis subjects, the median incidence risk score of colorectal carcinoma was 0.6402 in active ulcerative colitis subjects, significantly higher than that in remissive subjects (0.3114). Evaluation of two other independent datasets yielded similar results. Moreover, we found that the score significantly positively correlated with the degree of dysplasia in the case of colorectal adenomas. In the merged dataset, the median incidence risk score was 0.9027 among high-grade adenoma samples, significantly higher than that among low-grade adenomas (0.8565). In summary, the developed incidence risk score could well predict the incidence risk of precancerous colorectal lesions and has value in clinical application.

评估癌前大肠病变患者的癌症发生风险是有意义的。比较通过多个平台测量的大肠癌患者的样本内相对表达顺序（REO）与正常大肠组织的样本内相对表达顺序，在训练数据中鉴定了由1,840个基因对组成的定性转录特征。在16个活动和18个非活动（缓解）溃疡性结肠炎受试者的评估数据集中，活动性溃疡性结肠炎受试者的结肠直肠癌的中位发病风险评分为0.6402，显着高于缓解性结肠炎受试者（0.3114）。对其他两个独立数据集的评估得出了相似的结果。此外，我们发现在结直肠腺瘤的情况下，评分与异型增生程度显着正相关。在合并的数据集中，高级腺瘤样本的中位发病风险评分为0.9027，显着高于低级腺瘤（0.8565）。综上所述，建立的发病风险评分可以很好地预测癌前大肠病变的发病风险，在临床应用中具有一定的价值。