Introduction: We sought to verify the predicting role of a favorable profile on computed tomography perfusion (CTP) in the outcome of patients with acute ischemic stroke (AIS) due to large vessel occlusion (LVO) undergoing effective mechanical thrombectomy (MT). Methods: We retrospectively enrolled 25 patients with AIS due to LVO and with a CTP study showing the presence of ischemic penumbra who underwent effective MT, regardless of the time of onset. The controls were 25 AIS patients with overlapping demographics and clinical and computed tomography angiography features at admission who had undergone successful MT within 6 h from onset and without a previous CTP study. The outcome measure was the modified Rankin Scale (mRS) score at 90 days. Results: Sixty-four percent of the study patients had an mRS score of 0–1 at 90 days versus 12% of the control patients (p #x3c; 0.001). Patients of the study group had a more favorable distribution of disability scores (median mRS [IQR] score of 0 [0–2] vs. 2 [2–3]). Multivariate analysis showed that the selection of patients based on a favorable CTP study was strongly associated (p #x3c; 0.001) with a better neurological outcome. Conclusions: In our small-sized and retrospective study, the presence of ischemic penumbra was associated with a better clinical outcome in patients with AIS due to LVO after MT. In the future, a larger and controlled study with similar criteria of enrollment is needed to further validate the role of CTP in patient selection for MT, regardless of the time from the onset of symptoms.
Cerebrovasc Dis Extra 2021;11:1–8

中文翻译：

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有利灌注成像在预测接受有效血栓切除术的大血管闭塞引起的急性缺血性卒中患者的预后中的作用：单中心研究

简介：我们试图验证有利的分布图对计算机断层扫描灌注（CTP）在因大血管阻塞（LVO）接受有效机械血栓切除术（MT）而导致的急性缺血性卒中（AIS）患者的预后中的预测作用。方法：我们回顾性研究了25例因LVO引起的AIS患者，并进行了一项CTP研究，该研究表明存在缺血性半影​​的患者均接受了有效的MT，无论其发病时间如何。对照组为25例入院时具有重叠的人口统计学特征，临床和计算机断层摄影血管造影特征的AIS患者，这些患者在发病后6小时内成功完成MT且未进行过CTP研究。结局指标为90天时的改良Rankin量表（mRS）评分。结果：有64％的研究患者在90天时的mRS评分为0-1，而对照组为12％（p＃x3c; 0.001）。研究组患者的残疾评分分布更有利（中位mRS [IQR]评分分别为0 [0-2]和2 [2-3]）。多变量分析显示，基于良好的CTP研究选择的患者与较好的神经系统结局密切相关（p＃x3c; 0.001）。结论：在我们的小型回顾性研究中，缺血性半影​​的存在与MT术后LVO引起的AIS患者的临床预后更好相关。将来，无论症状出现的时间如何，都需要一项更大的，具有相似注册标准的对照研究来进一步验证CTP在MT患者选择中的作用。
Cerebrovasc Dis Extra 2021; 11：1–8