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Evaluation of Antithrombogenic pHPC on CoCr Substrates for Biomedical Applications
Coatings ( IF 3.4 ) Pub Date : 2021-01-15 , DOI: 10.3390/coatings11010093
Catrin Bannewitz , Tim Lenz-Habijan , Jonathan Lentz , Marcus Peters , Volker Trösken , Sabine Siebert , Sebastian Weber , Werner Theisen , Hans Henkes , Hermann Monstadt

Bare metal endovascular implants pose a significant risk of causing thrombogenic complications. Antithrombogenic surface modifications, such as phenox’s “Hydrophilic Polymer Coating” (pHPC), which was originally developed for NiTi implants, decrease the thrombogenicity of metal surfaces. In this study, the transferability of pHPC onto biomedical CoCr-based alloys is examined. Coated surfaces were characterized via contact-angle measurement and atomic force microscopy. The equivalence of the antithrombogenic effect in contact with whole human blood was demonstrated in vitro for CoCr plates compared to NiTi plates on a platform shaker and for braided devices in a Chandler loop. Platelet adhesion was assessed via scanning electron microscopy and fluorescence microscopy. The coating efficiency of pHPC on CoCr plates was confirmed by a reduction of the contact angle from 84.4° ± 5.1° to 36.2° ± 5.2°. The surface roughness was not affected by the application of pHPC. Platelet adhesion was significantly reduced on pHPC-coated specimens. The platelet covered area was reduced by 85% for coated CoCr plates compared to uncoated samples. Uncoated braided devices were completely covered by platelets, while on the pHPC-coated samples, very few platelets were visible. In conclusion, the antithrombogenic effect of pHPC coating can be successfully applied on CoCr plates as well as stent-like CoCr braids.

中文翻译:

用于生物医学应用的CoCr基质上抗血栓形成的pHPC的评估

裸金属血管内植入物具有引起血栓形成并发症的重大风险。抗血栓形成的表面改性(例如最初为NiTi植入物开发的phenox的“亲水性聚合物涂层”(pHPC))降低了金属表面的血栓形成性。在这项研究中,检查了pHPC在生物医学CoCr基合金上的转移能力。通过接触角测量和原子力显微镜表征涂层表面。与平台振动器上的NiTi板相比,CoCr板与钱德勒回路中的编织装置相比,在体外证明了与全人血接触的抗血栓形成作用的等效性。通过扫描电子显微镜和荧光显微镜评估血小板粘附。通过将接触角从84.4°±5.1°减小到36.2°±5.2°,可以确认pHPC在CoCr板上的涂覆效率。表面粗糙度不受pHPC的影响。在涂有pHPC的标本上,血小板粘附力显着降低。与未涂覆的样品相比,涂覆的CoCr板的血小板覆盖面积减少了85%。未涂覆的编织装置完全被血小板覆盖,而在pHPC涂覆的样品上,几乎看不到血小板。总之,pHPC涂层的抗血栓形成作用可以成功地应用于CoCr板以及类似支架的CoCr编织层。与未涂覆的样品相比,涂覆的CoCr板的血小板覆盖面积减少了85%。未涂覆的编织装置完全被血小板覆盖,而在pHPC涂覆的样品上,几乎看不到血小板。总之,pHPC涂层的抗血栓形成作用可以成功地应用于CoCr板以及类似支架的CoCr编织层。与未涂覆的样品相比,涂覆的CoCr板的血小板覆盖面积减少了85%。未涂覆的编织装置完全被血小板覆盖,而在pHPC涂覆的样品上,几乎看不到血小板。总之,pHPC涂层的抗血栓形成作用可以成功地应用于CoCr板以及类似支架的CoCr编织层。
更新日期:2021-01-15
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