The study aims to evaluate the effectiveness of local injection of autologous platelet rich plasma (A-PRP) as a treatment for women suffering from stress urinary incontinence (SUI). In a prospective intervention study, twenty consecutive women suffering from SUI were treated with A-PRP injection at anterior vaginal wall where mid-urethra locates. Self-reported questionnaires were used to measure pre-treatment, 1 month and 6 months post-treatment symptom severity. Secondary outcomes of sexual function and treatment effect sorted by age were analyzed with valid statistical methods. A-PRP is effective in relieving SUI symptoms at both 1 month and 6 months post-treatment without significant adverse reactions reported. It seems to have a trend that treatment success rate with cured and improved symptoms was slightly higher in the younger group, although it did not reach statistical significance (P = 0.07). No significant changes in sexual function before and after the treatment were reported by the patients. This pilot study is the first to report A-PRP treatment effect for SUI in women. The result suggested that A-PRP is a considerable treatment option for mild to moderate SUI cases. It also opens up further research opportunities for A-PRP’s clinical applications.

该研究旨在评估局部注射自体富血小板血浆 (A-PRP) 作为治疗压力性尿失禁 (SUI) 女性的有效性。在一项前瞻性干预研究中，连续 20 名患有 SUI 的女性在中尿道所在的阴道前壁注射 A-PRP。自我报告的问卷用于测量治疗前、治疗后 1 个月和 6 个月的症状严重程度。使用有效的统计方法分析按年龄排序的性功能和治疗效果的次要结果。A-PRP 可有效缓解治疗后 1 个月和 6 个月的 SUI 症状，且未报告显着不良反应。似乎有一种趋势，即年轻组治愈和改善症状的治疗成功率略高，P  = 0.07）。患者报告治疗前后性功能无明显变化。该试点研究首次报告了 A-PRP 对女性 SUI 的治疗效果。结果表明，A-PRP 是轻度至中度 SUI 病例的重要治疗选择。它还为 A-PRP 的临床应用开辟了进一步的研究机会。