While spectacular successes have been achieved in homogeneous catalysis with the use of achiral diphosphine ligands featuring a wide natural bite angle, such as XantPhos, chiral diphosphines that can induce a large P–M–P bite angle in their transition metal complexes are conspicuously less explored in asymmetric catalysis, probably due to the challenges in the identification and efficient construction of a suitable chiral backbone. In the past decade, a highly efficient synthesis of chiral aromatic spiroketals and the corresponding diphosphine ligands (SKPs) has been developed in this group.

中文翻译：

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一种不对称催化结构适应性芳族螺旋基手性二膦配体。

尽管使用具有宽自然咬合角的非手性二膦配体（如XantPhos）在均相催化方面取得了惊人的成功，但在过渡金属络合物中可诱导大P–M–P咬合角的手性二膦化合物却很少被探索。在不对称催化中，可能是由于鉴定和有效构建合适的手性骨架的挑战。在过去的十年中，该组已开发出高效合成手性芳族螺环酮和相应的二膦配体（SKP）的方法。