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Design and development of solid lipid nanoparticles of tazarotene for the treatment of psoriasis and acne: a quality by design approach
Materials Technology ( IF 3.1 ) Pub Date : 2021-01-15 , DOI: 10.1080/10667857.2021.1873637
Sanjay Sharma 1 , Abhishek Kanugo 1 , Juilee Gaikwad 1
Affiliation  

ABSTRACT

Tazarotene is a third-generation retinoid applied topically for the treatment of psoriasis and acne. But its applications are limited due to its poor solubility and bioavailability. The current investigation aimed at the development of solid lipid nanoparticles (SLN) of Tazarotene for effective topical delivery. Depending on the solubility, stability, and compatibility lipids and surfactants were selected and further optimised. SLN of Tazarotene was developed by hot-homogenisation followed by probe sonication method. Preformulation studies were carried out and compatibility was confirmed with FTIR. The design of the expert, Box Behnken model was implemented and the surface response curve was plotted. Glyceryl monostearate was found to be the best lipid and a combination of tween-span as a surfactant for SLNs. The entrapment efficiency was found as 59% and the particle size of 470 nm was reported. The optimised batch showed the zeta potential of −10.3 Mv with a drug release of 59% to 77% after 6 h.



中文翻译:

用于治疗银屑病和痤疮的他扎罗汀固体脂质纳米颗粒的设计和开发:质量源于设计的方法

摘要

他扎罗汀是第三代维甲酸,用于治疗银屑病和痤疮。但由于其溶解度和生物利用度差,其应用受到限制。目前的研究旨在开发他扎罗汀的固体脂质纳米颗粒 (SLN),以实现有效的局部给药。根据溶解度、稳定性和相容性,选择并进一步优化脂质和表面活性剂。他扎罗汀的 SLN 是通过热均化后探针超声法开发的。进行了预制剂研究,并确认了与 FTIR 的相容性。实施了专家 Box Behnken 模型的设计,并绘制了表面响应曲线。单硬脂酸甘油酯被发现是最好的脂质和吐温跨度的组合作为 SLN 的表面活性剂。发现包埋效率为 59%,粒径为 470 nm。优化后的批次显示 zeta 电位为 -10.3 Mv,6 小时后药物释放率为 59% 至 77%。

更新日期:2021-01-15
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