Renal cell carcinomas (RCCs) account for about 90% of renal tumors, and their major histological subtype is ccRCC (clear cell RCC). Increasing evidence has indicated that the tumor microenvironment plays a significant role in the occurrence and development of ccRCC. In this study, we used ESTIMATE and CIBERSORT computational methods to calculate the proportion of immune and stromal components and the rate of TICs (tumor‐infiltrating immune cells) in 539 ccRCC samples from The Cancer Genome Atlas database. By examining the intersection of the differentially expressed genes obtained by the protein–protein interaction network and Cox regression analysis, we identified only one overlapping gene: IGLL5 (immunoglobulin lambda‐like polypeptide 5). We report that IGLL5 expression is correlated with TICs. Furthermore, our immunoinfiltration analyses revealed that three types of TIC are positively correlated with IGLL5 expression. IGLL5 may have potential as a prognostic biomarker of ccRCC.

中文翻译：

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IGLL5与透明细胞肾细胞癌的肿瘤浸润免疫细胞相关

肾细胞癌（RCC）约占肾肿瘤的 90%，其主要组织学亚型是 ccRCC（透明细胞 RCC）。越来越多的证据表明肿瘤微环境在ccRCC的发生和发展中起着重要作用。在这项研究中，我们使用 ESTIMATE 和 CIBERSORT 计算方法来计算来自癌症基因组图谱数据库的 539 个 ccRCC 样本中免疫和基质成分的比例以及 TIC（肿瘤浸润免疫细胞）的比率。通过检查蛋白质-蛋白质相互作用网络和 Cox 回归分析获得的差异表达基因的交集，我们仅鉴定了一个重叠基因：IGLL5（免疫球蛋白 λ 样多肽 5）。我们报告说IGLL5表达与 TIC 相关。此外，我们的免疫浸润分析显示三种类型的 TIC 与IGLL5表达呈正相关。IGLL5可能具有作为 ccRCC 预后生物标志物的潜力。