Chagas disease (CD) is a global health concern with approximately 12 000 deaths per year worldwide. In the chronic phase, about 30% of patients develop the cardiac clinical form, which presents symptoms associated with the presence of inflammatory cells in the cardiac tissue. Neutrophils are inflammatory cells able to modulate the chronic immune response against pathogens. These cells are capable of interacting with Trypanosoma cruzi, the aetiological agent of CD, and perform several effector functions, such as NET release. However, few studies have been carried out to investigate the role of these cells in the disease.

中文翻译：

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与健康个体的中性粒细胞相比，患有心脏临床形式的恰加斯病患者的中性粒细胞释放的 NET 更少

恰加斯病 (CD) 是一种全球性的健康问题，全世界每年约有 12 000 人死亡。在慢性期，大约 30% 的患者出现心脏临床表现，其表现出与心脏组织中存在炎性细胞相关的症状。中性粒细胞是能够调节针对病原体的慢性免疫反应的炎症细胞。这些细胞能够与CD 的病原体克氏锥虫相互作用，并执行多种效应功能，例如 NET 释放。然而，很少有研究调查这些细胞在疾病中的作用。