Stereotactic radiosurgery (SRS) has become a primary treatment for multiple brain metastases (BM) but may require distribution of BMs over several sessions to make delivery time and radiation toxicity manageable. Contrasting to equal fraction dose in conventional fractionation, distributed SRS delivers full dose to a subset of BMs in each session while avoiding adjacent BMs in the same session to reduce toxicity from overlapping radiation. However, current clinical treatment planning for distributed SRS relies on manual BM assignment, which can be tedious and error prone. This work describes a novel approach to automate the distribution of BM in the Gamma Knife (GK) clinical workflow.

中文翻译：

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多发性脑转移瘤分布式治疗的通用算法

立体定向放射外科 (SRS) 已成为多发性脑转移瘤 (BM) 的主要治疗方法，但可能需要在多个疗程中分布 BM，以使交付时间和放射毒性可控。与传统分割中的等分数剂量相比，分布式 SRS 在每个会话中向 BM 子集提供全剂量，同时避免在同一会话中相邻的 BM，以减少重叠辐射的毒性。然而，目前分布式 SRS 的临床治疗计划依赖于手动 BM 分配，这可能是乏味且容易出错的。这项工作描述了一种在伽玛刀 (GK) 临床工作流程中自动分配 BM 的新方法。