Nonionic double thermoresponsive diblock copolymers with both upper critical solution temperature (UCST) and lower critical solution temperature (LCST) phase transitions are synthesized via eco‐friendly photoiniferter reversible addition–fragmentation chain transfer polymerization. While the biocompatible random copolymer of di(ethylene glycol) methyl ether methacrylate and oligo(ethylene glycol) methacrylate accounts for the LCST transition, the block of polymethacrylamide from an easily accessible monomer with low health hazard is responsible for the UCST transition. Temperature‐dependent dynamic light scattering measurements confirm the formation of micellar aggregates in water at the temperatures below UCST‐ and above LCST‐type cloud points. Additionally, the temperature interval between UCST and LCST, where both blocks are dissolved, can be tailored by varying the comonomer ratio in the random copolymer block. With these unique advantages, the presented work introduces a new polymer system for the design of schizophrenic polymers.

中文翻译：

---

通过PhotoRAFT聚合合成具有可调热响应性的非离子型UCST–LCST二嵌段共聚物

具有较高临界溶液温度（UCST）和较低临界溶液温度（LCST）相变的非离子双热响应性双嵌段共聚物是通过生态友好的光引发剂可逆加成-断裂链转移聚合反应合成的。虽然二乙二醇乙二醇甲基丙烯酸甲酯和甲基丙烯酸乙二醇乙二醇酯的生物相容性无规共聚物是LCST过渡的原因，但是聚甲基丙烯酰胺的嵌段是由易于获取的，对健康危害低的单体造成的，是UCST过渡的原因。依赖温度的动态光散射测量结果证实，在低于UCST和高于LCST型浊点的温度下，胶束聚集体的形成。此外，UCST和LCST之间的温度间隔（两个模块都溶解在其中）可以通过改变无规共聚物嵌段中的共聚单体比例来定制。凭借这些独特的优势，本工作介绍了一种用于设计精神分裂症聚合物的新型聚合物系统。