The longevity gene Klotho and its cerebrospinal fluid protein profiles as a modifier for Parkinson´s disease,European Journal of Neurology

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The longevity gene Klotho and its cerebrospinal fluid protein profiles as a modifier for Parkinson´s disease
European Journal of Neurology ( IF 5.1 ) Pub Date : 2021-01-15 , DOI: 10.1111/ene.14733
Milan Zimmermann _{1,

2} , Leonie Köhler ₁ , Marketa Kovarova ₃ , Stefanie Lerche _{1,

2} , Claudia Schulte _{1,

2} , Isabel Wurster _{1,

2} , Gerrit Machetanz _{1,

2} , Christian Deuschle _{1,

2} , Ann-Kathrin Hauser _{1,

2} , Thomas Gasser _{1,

2} , Daniela Berg _{1,

4} , Erwin Schleicher ₃ , Walter Maetzler ₄ , Kathrin Brockmann _{1,

2}

Affiliation

Parkinson´s disease (PD) has a large phenotypic variability, which may, at least partly, be genetically driven including alterations of gene products. Candidates might not only be proteins associated with disease risk but also pathways that play a role in aging.

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