Background

Prevalence of obesity, hypertension and dyslipidemia has been increasing in children and adolescents worldwide. Exposure to environmental pollutants may contribute to this development. Our aim was to study associations between perfluoroalkyl substances (PFAS) and dyslipidemia, hypertension and obesity in a population-based sample of adolescents.

Methods

Serum PFAS concentrations were measured in 940 adolescents, mean age 16.4 (SD 1.3) years, from the cross-sectional Fit Futures study by the UHPLC-MS/MS method. The following endpoints were used: hypertension (systolic blood pressure over 130 mmHg and/or diastolic blood pressure over 80 mmHg); obesity (body mass index over 2 z-score, WHO charts for adolescents); dyslipidemia (total cholesterol ≥ 5.17 mmol/L, and/or LDL-cholesterol ≥ 3.36 mmol/l, and/or apolipoprotein B ≥ 1.10 g/L).

Results

Perfluorooctane sulfonate (PFOS), perfluorononanoate (PFNA), perfluorodecanoate (PFDA) and perfluoroundecanoate (PFUnDA) serum concentrations were positively associated with apolipoprotein B, total- and LDL cholesterol. The highest vs. lowest quartiles of total PFAS (∑PFAS), PFNA and PFDA concentrations were positively associated with the risk of dyslipidemia: OR 2.24 (95% CI 1.10–4.54), OR 2.30 (95% CI 1.16–4.57) and 2.36 (95% CI 1.08–5.16), respectively. The highest vs. lowest quartiles of ∑PFAS, perfluorohexane sulfonate (PFHxS), PFOS, perfluorooctanoate (PFOA) concentrations were positively associated with the risk of hypertension: OR 1.91 (95% CI 1.12–3.26), OR 2.06 (95% CI 1.16–3.65), 1.86 (95% CI 1.08–3.19) and 2.08 (95% CI 1.17–3.69) respectively. PFHxS and perfluoroheptane sulfonate (PFHpS) concentrations were positively associated with obesity.

Conclusions

This cross-sectional study showed a possible link between several PFAS and dyslipidemia, hypertension and obesity in Norwegian adolescents.

中文翻译：

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青少年接触全氟烷基物质（PFAS）和血脂异常，高血压和肥胖。健康期货研究

背景

肥胖，高血压和血脂异常的患病率在全世界的儿童和青少年中一直在增加。暴露于环境污染物可能有助于这一发展。我们的目标是研究以人群为基础的青少年全氟烷基物质（PFAS）与血脂异常，高血压和肥胖之间的关联。

方法

通过UHPLC-MS / MS方法从“ Fit Futures”横断面研究中，在940名平均年龄16.4（SD 1.3）岁的青少年中测量了PFAS浓度。使用了以下终点指标：高血压（收缩压超过130 mmHg和/或舒张压超过80 mmHg）；肥胖（体重指数超过2个z评分，WHO青少年图表）；血脂异常（总胆固醇≥5.17 mmol / L，和/或LDL-胆固醇≥3.36 mmol / L，和/或载脂蛋白B≥1.10 g / L）。

结果

全氟辛烷磺酸（PFOS），全氟壬酸（PFNA），全氟癸酸（PFDA）和全氟十一酸（PFUnDA）血清浓度与载脂蛋白B，总胆固醇和LDL胆固醇呈正相关。总PFAS（∑PFAS），PFNA和PFDA浓度的最高四分位数与最低四分位数与血脂异常风险呈正相关：OR 2.24（95％CI 1.10-4.54），OR 2.30（95％CI 1.16-4.57）和2.36 （95％CI 1.08–5.16）。∑PFAS，全氟己烷磺酸盐（PFHxS），PFOS，全氟辛酸盐（PFOA）浓度的最高四分位数与最低四分位数与高血压风险呈正相关：OR 1.91（95％CI 1.12–3.26），或2.06（95％CI 1.16 –3.65），1.86（95％CI 1.08–3.19）和2.08（95％CI 1.17–3.69）。

结论

这项横断面研究表明，几种PFAS与挪威青少年血脂异常，高血压和肥胖症之间可能存在联系。