Increasing acidity is an effective method for bacterial inactivation by inhibiting the synthesis of intracellular proteins at low pH. Photo-driven proton release probe can be used for the measurement of proton in hydrophobic condition. To develop fluorescent proton donor, two boron dipyrromethene derivatives (BDP-S and BDP-S2) were characterized by spectroscopic methods. Irradiation of BDP-S by white LED light resulted in efficient generation of acidic species with changes of fluorescence emission. The linear relationship between the pH value and the fluorescence intensity of BDP-S was obtained, indicating that BDP-S is a fluorescent visual proton donor. Light-induced antibacterial results indicate that BDP-S can significantly inhibit the growth of E. coli. The results prove that BDP-S is a very promising photoacid sterilant.

增加酸度是通过抑制低 pH 值下细胞内蛋白质的合成来灭活细菌的有效方法。光驱动质子释放探针可用于疏水条件下质子的测量。为了开发荧光质子供体，通过光谱方法表征了两种硼二吡咯亚甲基衍生物（BDP-S 和 BDP-S2）。用白光 LED 光照射 BDP-S 可有效产生酸性物质，并改变荧光发射。得到pH值与BDP-S荧光强度的线性关系，表明BDP-S是荧光视觉质子供体。光诱导抗菌结果表明BDP-S能显着抑制大肠杆菌的生长. 结果证明BDP-S是一种很有前途的光酸杀菌剂。