Two undescribed Tricholoma triterpenoids, namely tricholopardins C (1) and D (2), were isolated from the wild mushroom Tricholoma pardinum. Their structures with absolute configurations were elucidated by spectroscopic methods, as well as the single crystal X-ray diffraction. Compounds 1 and 2 were further obtained by chemical conversions from the known analogues. Compound 1 showed significant cytotoxicity to MCF-7 and Hela cell lines with IC₅₀ values of 4.7 μM and 9.7 μM, respectively. Its mechanism of inducing MCF-7 cell apoptosis was studied briefly.

Graphical Abstract

中文翻译：

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结构，化学转化，和Tricholopardins C和D，从野生蘑菇Tricholoma pardinum的两个Tricholoma triterpenoids的细胞毒性

从野生蘑菇Tricholoma pardinum中分离出两种未描述的口蘑三萜，即口蘑C（1）和D（2）。通过光谱方法以及单晶X射线衍射阐明了它们具有绝对构型的结构。通过化学转化从已知的类似物进一步获得化合物1和2。化合物1对MCF-7和Hela细胞系显示出明显的细胞毒性，IC ₅₀值分别为4.7μM和9.7μM。简要研究了其诱导MCF-7细胞凋亡的机制。

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