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Role of Glucose Metabolism and Mitochondrial Function in Diabetic Kidney Disease
Current Diabetes Reports ( IF 4.2 ) Pub Date : 2021-01-15 , DOI: 10.1007/s11892-020-01372-2
Robert C. Stanton

Purpose of Review

Diabetic kidney disease (DKD) continues to be the primary cause of chronic kidney disease in the USA and around the world. The numbers of people with DKD also continue to rise despite current treatments. Certain newer hypoglycemic drugs offer a promise of slowing progression, but it remains to be seen how effective these will be over time. Thus, continued exploration of the mechanisms underlying the development and progression of DKD is essential in order to discover new treatments. Hyperglycemia is the main cause of the cellular damage seen in DKD. But, exactly how hyperglycemia leads to the activation of processes that are ultimately deleterious is incompletely understood.

Recent Findings

Studies primarily over the past 10 years have provided novel insights into the interplay of hyperglycemia, glucose metabolic pathways, mitochondrial function, and the potential importance of what has been called the Warburg effect on the development and progression of DKD.

Summary

This review will provide a brief overview of glucose metabolism and the hypotheses concerning the pathogenesis of DKD and then discuss in more detail the supporting data that indicate a role for the interplay of glucose metabolic pathways and mitochondrial function.



中文翻译:

葡萄糖代谢和线粒体功能在糖尿病肾病中的作用

审查目的

糖尿病肾病(DKD)继续是美国和世界范围内慢性肾脏病的主要原因。尽管有目前的治疗方法,但DKD患者的人数也继续增加。某些新型降血糖药有望减缓病情发展,但随着时间的推移,这些药的有效性还有待观察。因此,为了发现新的治疗方法,持续探索DKD发生和发展的机制至关重要。高血糖症是导致DKD发生细胞损伤的主要原因。但是,高血糖症到底如何导致最终有害的过程的激活尚不完全清楚。

最近的发现

过去10年中的主要研究为高血糖,葡萄糖代谢途径,线粒体功能之间的相互作用以及所谓的Warburg效应对DKD的发展和发展的潜在重要性提供了新颖的见解。

概要

这篇综述将简要概述葡萄糖代谢以及有关DKD发病机理的假设,然后更详细地讨论表明葡萄糖代谢途径与线粒体功能相互作用的支持性数据。

更新日期:2021-01-15
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