Male reproductive dysfunction is one of the common complications of diabetes mellitus that causes infertility. This study was designed to investigate the protective effect of Momordica cymbalaria (M. cymbalaria) extracts on diabetes mediated reproductive toxicity in male Wistar rats. The induction of diabetes was performed using a single intraperitoneal injection of alloxan (120 mg/kg). Skin and seed extracts (250 and 500 mg/kg) of M. cymbalaria were orally administered to alloxan-induced diabetic male rats for 28 days. Postprandial blood glucose (PBG) levels were recorded at 7-day interval for four weeks. The effects of the treatment on blood glucose, weight of reproductive organs, sperm count, testosterone levels, antioxidant capacity, and histomorphology were evaluated. Treatment with the above extracts of M. cymbalaria significantly (p < 0.05) improved the reproductive parameters as well as the antioxidant levels superoxide dismutase (SOD) and glutathione-s-transferase (GST) in the diabetic rats. Also, oral treatment with M. cymbalaria extracts significantly reduced the PBG and malondialdehyde (MDA) levels. Further, it revived the histomorphology of reproductive organs in diabetic rats. Interestingly, skin extract at a dose of 500 mg/kg was found to be more efficient in elevating the level of testosterone and sperm count in the diabetic rats. Based on the results, it is clear that M. cymbalaria not only regulates the postprandial blood glucose levels but also improves the reproductive health in the diabetic state.

男性生殖功能障碍是导致不孕的糖尿病常见并发症之一。本研究旨在研究苦瓜（M. cymbalaria）提取物对雄性 Wistar 大鼠糖尿病介导的生殖毒性的保护作用。使用单次腹膜内注射四氧嘧啶 (120 mg/kg) 进行糖尿病的诱导。M. cymbalaria的皮肤和种子提取物（250 和 500 mg/kg）口服给予四氧嘧啶诱导的糖尿病雄性大鼠 28 天。每隔 7 天记录一次餐后血糖 (PBG) 水平，持续 4 周。评估了治疗对血糖、生殖器官重量、精子数量、睾酮水平、抗氧化能力和组织形态学的影响。用上述cymbalaria提取物处理显着 ( p  < 0.05) 改善了糖尿病大鼠的生殖参数以及超氧化物歧化酶 (SOD) 和谷胱甘肽-s-转移酶 (GST) 的抗氧化水平。此外，用M. cymbalaria进行口服治疗提取物显着降低了 PBG 和丙二醛 (MDA) 水平。此外，它恢复了糖尿病大鼠生殖器官的组织形态学。有趣的是，发现 500 mg/kg 剂量的皮肤提取物在提高糖尿病大鼠的睾酮水平和精子数量方面更有效。根据结果​​，很明显，M. cymbalaria不仅可以调节餐后血糖水平，还可以改善糖尿病患者的生殖健康。