The outbreak of Severe Acute Respiratory Syndromes Coronavirus-2 (SARS-CoV-2) is a global catastrophe. The elderly and people with co-morbidity are facing a serious complication of the disease. The entry and infection strategy of SARS-CoV-2 in a host cell is raised by an amazing way of ACE2 receptor recognition and imbalance of ACE/ACE2 in various organs, especially in the lungs. Here it has been discussed that during the receptor-recognition (beginning of infection), interferon, protease and followed by cytokine induction, hypoxia plays a significant role in the context of the balance of ACE/ACE2. It has also been very concisely delineated the biochemistry and mechanism of ACE/ACE2 balance in different stages of infection and its role in comorbidity.

中文翻译：

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ACE / ACE2平衡可能有助于解释某些合并症导致严重的COVID-19病例。

严重急性呼吸系统综合症冠状病毒2（SARS-CoV-2）的爆发是全球性的灾难。老年人和合并症患者正面临这种疾病的严重并发症。SARS-CoV-2在宿主细胞中的进入和感染策略是通过ACE2受体识别的惊人方式以及各种器官（尤其是肺脏）中ACE / ACE2失衡的惊人方式而提出的。在此已经讨论过，在受体识别（感染开始），干扰素，蛋白酶以及随后的细胞因子诱导过程中，缺氧在ACE / ACE2平衡的背景下起着重要作用。还已经非常简洁地描述了在感染的不同阶段ACE / ACE2平衡的生物化学和机理及其在合并症中的作用。