Three-dimensional (3D) printing technology with satisfactory speed and accuracy has been a powerful force in biomaterial processing. Early studies on 3D printing of biomaterials mainly focused on their biocompatibility and cellular viability while rarely attempted to produce robust specimens. Nonetheless, the biomedical applications of polymers can be severely limited by their inherently weak mechanical properties particularly in bone tissue engineering. In this study, continuous liquid interface production (CLIP) is applied to construct 3D objects of nano-hydroxyapatite (n-HA) filled polymeric biomaterials with complex architectures. Notably, the bioactive and osteoconductive n-HA endows the 3D prints of poly(ethyleneglycol)diacrylate (PEGDA) composites with a high compression strength of 6.5 ± 1.4 MPa, about 342% improvement over neat PEGDA. This work demonstrates the first successful attempt on CLIP 3D printing of n-HA nanocomposites, providing a feasible, cost-effective and patient-specific solution to various fields in the biomedical industry.

中文翻译：

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通过连续的液体界面生产，对坚固且生物相容的聚（乙二醇）二丙烯酸酯/纳米羟基磷灰石复合材料进行3D打印

具有令人满意的速度和精度的三维（3D）打印技术一直是生物材料加工中的强大力量。早期对生物材料进行3D打印的研究主要集中在它们的生物相容性和细胞生存力上，而很少尝试制作坚固的标本。但是，聚合物的生物医学应用可能会因其固有的较弱的机械性能而受到严重限制，特别是在骨组织工程中。在这项研究中，连续液体界面生产（CLIP）被用于构造具有复杂结构的纳米羟基磷灰石（n-HA）填充的聚合物生物材料的3D对象。值得注意的是，具有生物活性和骨传导性的n-HA赋予聚（乙二醇）二丙烯酸酯（PEGDA）复合材料3D打印物以6.5±1.4 MPa的高抗压强度，比纯PEGDA高约342％。