A series of glycoside–peptide conjugates were prepared by engineering at the N-terminus of the natural peptide gramicidin A. The conjugate containing galactose moiety formed a unimolecular transmembrane channel and mediated ion transport to induce apoptosis of cancer cells. More importantly, it exhibited liver cancer cell-targeting behavior due to the galactose–asialoglycoprotein receptor recognition.

中文翻译：

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基于Gramicidin A的单分子通道：癌细胞的靶向行为和离子转运诱导的细胞凋亡

通过在天然肽短杆菌肽A的N端工程改造，制备了一系列糖苷肽结合物。含有半乳糖部分的结合物形成了单分子跨膜通道并介导了离子迁移，从而诱导了癌细胞的凋亡。更重要的是，由于半乳糖-亚糖糖蛋白受体的识别，它表现出了针对肝癌细胞的靶向行为。