Fast time-gated single-photon detectors demonstrated high depth sensitivity in the detection of localized absorption perturbations inside scattering media, but their use for in vivo clinical applications—such as functional imaging of brain activation—was impaired by their small (${\lt}{0.04}\;{\rm{mm}}^2$) active area. Here, we demonstrate, both on phantoms and in vivo, the performance of a fast-gated digital silicon photomultiplier (SiPM) that features an overall active area of ${8.6}\;{\rm{mm}}^2$, overcoming the photon collection capability of established time-gated single-pixel detectors by orders of magnitude, enabling deep investigations within scattering media and high signal-to-noise ratios at late photon arrival times.

中文翻译：

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具有8.6 mm ²快速选通SiPM的时域漫射光学元件，可实现极佳的光收集

快速时间选通单光子探测器证明在检测局部吸收扰动的高深度灵敏度内的散射介质，但是它们的使用在体内临床应用，如脑激活物通过其小（受损的功能成像$ {\ LT } {0.04} \; {\ rm {mm}} ^ 2 $）有效区域。在这里，我们在幻像和体内都演示了快速门控数字硅光电倍增管（SiPM）的性能，该器件的总有效面积为$ {8.6} \; {\ rm {mm}} ^ 2 $，可以克服建立的时间门控单像素检测器的光子收集能力提高了几个数量级，从而可以在散射介质中进行深入研究，并在光子到达后期达到高信噪比。