Blueberries are consumed as healthy fruits that provide a variety of benefits to the nervous system. Scientists have found that blueberries can be used as a daily edible source for supplementation to prevent and minimize complexities of age-related diseases as well as to improve learning and memory in children. Anthocyanins are the most mentioned compounds among the components in blueberries, as they play a major role in providing the health benefits of this fruit. However, while they are highly active in impeding biological impairment in neuronal functions, they have poor bioavailability. This review focuses on neurological investigations of blueberries from in vitro cell studies to in vivo studies, including animal and human studies, with respect to their positive outcomes of neuroprotection and intervention in neurodegenerative conditions. Readers will also find information on the bioavailability of anthocyanins and the considerable factors affecting them so that they can make informed decisions regarding the daily consumption of blueberries. In this context, the ways in which blueberries or blueberry supplementation forms are consumed and which of these forms is best for maximizing the health benefits of blueberries should be considered important decision-making factors in the consumption of blueberries; all of these aspects are covered in this review. Finally, we discuss recent technologies that have been employed to improve the bioavailability of blueberry anthocyanins in the development of effective delivery vehicles supporting brain health.

中文翻译：

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蓝莓补充剂在神经元健康和保护性技术中，可有效递送蓝莓花色苷

蓝莓是作为健康的水果食用的，对神经系统有多种益处。科学家发现，蓝莓可用作日常食用来源，可以补充蓝莓以预防和减少与年龄有关的疾病的复杂性，并改善儿童的学习和记忆能力。花色苷是蓝莓成分中最常提及的化合物，因为它们在提供这种水果的健康益处中起着重要作用。但是，尽管它们在阻止神经元功能的生物学损伤方面非常活跃，但它们的生物利用度却很差。这篇综述着重于蓝莓的神经学研究，从体外细胞研究到体内研究，包括动物和人类研究，都涉及蓝莓对神经保护和干预神经退行性疾病的积极作用。读者还将找到有关花青素生物利用度的信息以及影响花青素的重要因素，以便他们可以就蓝莓的日常食用做出明智的决定。在这种情况下，应将食用蓝莓或蓝莓补充剂的方式以及哪种形式最能最大程度地发挥蓝莓的健康益处，是食用蓝莓的重要决策因素；所有这些方面都包含在本评论中。最后，我们讨论了在开发支持脑部健康的有效运载工具的过程中，用于改善蓝莓花青素生物利用度的最新技术。