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Elevated levels of IgA and IgG2 in individuals with chronic spinal cord injury
The Journal of Spinal Cord Medicine ( IF 1.7 ) Pub Date : 2021-01-14
Aya Shnawa, Samuel Lee, Angelos Papatheodorou, Katie Gibbs, Adam Stein, Debra Morrison, Ona Bloom

Objectives

To determine circulating levels of antibodies (IgA, IgM, IgG1-4) in individuals with SCI as compared to uninjured individuals.

Study Design

Prospective, observational study.

Setting

Outpatient clinic of a Department of Physical Medicine and Rehabilitation and research institute in an academic medical center.

Participants

Individuals with chronic (≥ 1 year from injury) SCI and uninjured individuals.

Outcome Measures

Serum antibody titers were determined by commercial multiplex ELISA.

Results

Blood samples were collected from individuals with chronic SCI (N = 29, 83% males) and uninjured individuals (N = 25, 64% males). Among participants with SCI, the distribution of American Spinal Injury Association Impairment Scale (AIS) grades was: A (n = 15), B (n = 2), C (n = 4), D (n = 8). Neurological levels of injury were: cervical (n = 17), thoracic (n = 10), and lumbar (n = 2). IgA levels were significantly elevated in participants with SCI compared to uninjured participants (median: 1.98 vs. 1.21 mg/ml, P < 0.0001), with levels most elevated in individuals with motor complete injuries compared to uninjured participants (P < 0.0003). IgG2 antibodies were also significantly elevated in participants with SCI compared to uninjured participants (median: 5.98 vs. 4.37 mg/ml, P < 0.018).

Conclusions

To our knowledge, this study provides the first evidence of elevated IgA, the antibody type most prevalent at respiratory, genitourinary and gastrointestinal tracts, common sites of infections in individuals with SCI. IgG2 levels were also elevated in individuals with SCI. These data support further investigations of IgA and other antibody types in individuals with chronic SCI, which may be increasingly important in the context of emerging novel infectious diseases such as SARS-CoV-2.



中文翻译:

慢性脊髓损伤患者的IgA和IgG2水平升高

目标

为了确定与未受伤的个体相比,患有SCI的个体的抗体(IgA,IgM,IgG1-4)的循环水平。

学习规划

前瞻性观察研究。

设置

一家学术医学中心的物理医学与康复科和研究所的门诊。

参加者

患有慢性(≥1年受伤)SCI的个体和未受伤的个体。

结果指标

通过商业多重ELISA确定血清抗体滴度。

结果

从患有慢性脊髓损伤的个体(N  = 29,男性83%)和未受伤的个体(N  = 25,64%男性)采集血液样本。在参加SCI的参与者中,美国脊髓损伤协会损害量表(AIS)等级的分布为:A(n  = 15),B(n  = 2),C(n  = 4),D(n  = 8)。神经损伤程度为:颈椎(n  = 17),胸椎(n  = 10)和腰椎(n = 2)。与未受伤的参与者相比,SCI参与者的IgA水平显着升高(中位数:1.98 vs. 1.21 mg / ml,P <0.0001),与完全受伤的参与者相比,运动完全损伤患者中的IgA水平最高(P <0.0003)。与未受伤的参与者相比,SCI参与者的IgG2抗体也显着升高(中位数:5.98 vs. 4.37 mg / ml,P <0.018)。

结论

据我们所知,这项研究提供了IgA升高的首个证据,IgA是呼吸道,泌尿生殖道和胃肠道中最普遍的抗体类型,是SCI患者常见的感染部位。SCI患者的IgG2水平也升高。这些数据支持对患有慢性SCI的个体中IgA和其他抗体类型的进一步研究,这在新兴的新型传染病(如SARS-CoV-2)的背景下可能变得越来越重要。

更新日期:2021-01-14
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