当前位置: X-MOL 学术Bioelectromagnetics › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Retinal and Cortical Contributions to Phosphenes During Transcranial Electrical Current Stimulation
Bioelectromagnetics ( IF 1.9 ) Pub Date : 2021-01-13 , DOI: 10.1002/bem.22317
Ian D Evans 1, 2, 3, 4 , Stephen Palmisano 1, 2 , Rodney J Croft 1, 2, 3, 4
Affiliation  

It is generally believed that the phosphenes induced by transcranial electric current stimulation (tECS) are a product of retinal activation, even when electrode placement is directly over the primary visual cortex. However, the origins of these tECS‐induced phosphenes have not yet been conclusively determined. In this study, phosphene detection thresholds using an FPz‐Oz montage were compared with those from (i) an Oz‐Cz montage to determine whether prefrontal regions, such as the retina, contribute to phosphenes and (ii) an FPz‐Cz montage to determine whether the visual cortex in the occipital lobe contributes to phosphenes. Twenty‐two participants received transcranial current stimulation with each of these montages (as well as a T3‐T4 montage included for exploratory purposes) at 6, 10, 16, 20, 24, 28, and 32 Hz. To estimate differences in current density at the retina and occipital lobe across montages, modeling of current density at phosphene thresholds was measured across 20 head models. Consistent with the proposal that tECS‐induced phosphenes are generated in the retina, increasing current density near the retina (FPz‐Oz relative to Oz‐Cz montage) reduced phosphene thresholds. However, increasing current density near the occipital cortex (FPz‐Oz relative to FPz‐Cz montage) also reduced phosphene thresholds while also requiring less current density at the retina according to the modeling estimates. This suggests that tECS of this occipital cortex also contributed to phosphene perception. © 2020 Bioelectromagnetics Society.

中文翻译:

经颅电流刺激期间视网膜和皮质对幻视的贡献

人们普遍认为,经颅电流刺激 (tECS) 诱导的光幻视是视网膜激活的产物,即使电极放置在初级视觉皮层上也是如此。然而,这些 tECS 诱导的光幻视的起源尚未最终确定。在这项研究中,将使用 FPz-Oz 蒙太奇的光幻视检测阈值与 (i) Oz-Cz 蒙太奇的阈值进行比较,以确定前额叶区域,如视网膜,是否有助于光幻视和 (ii) FPz-Cz 蒙太奇确定枕叶中的视觉皮层是否有助于幻视。22 名参与者以 6、10、16、20、24、28 和 32 Hz 的频率接受了这些蒙太奇(以及包括用于探索目的的 T3-T4 蒙太奇)中的每一个的经颅电流刺激。为了估计蒙太奇之间视网膜和枕叶电流密度的差异,在 20 个头部模型中测量了光幻视阈值处的电流密度建模。与 tECS 诱导的光幻视在视网膜中产生的提议一致,增加视网膜附近的电流密度(FPz-Oz 相对于 Oz-Cz 蒙太奇)降低了光幻视阈值。然而,根据建模估计,增加枕叶皮层附近的电流密度(FPz-Oz 相对于 FPz-Cz 蒙太奇)也降低了光幻视阈值,同时还需要更少的视网膜电流密度。这表明该枕叶皮层的 tECS 也有助于光幻觉的感知。© 2020 生物电磁学学会。在 20 个头部模型中测量了光幻视阈值下的电流密度建模。与 tECS 诱导的光幻视在视网膜中产生的提议一致,增加视网膜附近的电流密度(FPz-Oz 相对于 Oz-Cz 蒙太奇)降低了光幻视阈值。然而,根据建模估计,增加枕叶皮层附近的电流密度(FPz-Oz 相对于 FPz-Cz 蒙太奇)也降低了光幻视阈值,同时还需要更少的视网膜电流密度。这表明该枕叶皮层的 tECS 也有助于光幻觉的感知。© 2020 生物电磁学学会。在 20 个头部模型中测量了光幻视阈值下的电流密度建模。与 tECS 诱导的光幻视在视网膜中产生的提议一致,增加视网膜附近的电流密度(FPz-Oz 相对于 Oz-Cz 蒙太奇)降低了光幻视阈值。然而,根据建模估计,增加枕叶皮层附近的电流密度(FPz-Oz 相对于 FPz-Cz 蒙太奇)也降低了光幻视阈值,同时还需要更少的视网膜电流密度。这表明该枕叶皮层的 tECS 也有助于光幻觉的感知。© 2020 生物电磁学学会。根据建模估计,增加枕叶皮层附近的电流密度(FPz-Oz 相对于 FPz-Cz 蒙太奇)也降低了光幻视阈值,同时还需要更少的视网膜电流密度。这表明该枕叶皮层的 tECS 也有助于光幻视的感知。© 2020 生物电磁学学会。根据建模估计,增加枕叶皮层附近的电流密度(FPz-Oz 相对于 FPz-Cz 蒙太奇)也降低了光幻视阈值,同时还需要更少的视网膜电流密度。这表明该枕叶皮层的 tECS 也有助于光幻觉的感知。© 2020 生物电磁学学会。
更新日期:2021-01-29
down
wechat
bug