Multidisciplinary care (MDC) has been the most recommended approach for symptom management in amyotrophic lateral sclerosis (ALS) but there is conflicting evidence about its effectiveness on survival and quality of life (QoL) of ALS patients. We conducted a systematic review to determine the effects of multidisciplinary care compared to general neurological care in survival and quality of life of ALS patients. A comprehensive literature search using Scopus, MEDLINE-PubMed, Cochrane, Web of Science, PEDro, and Science Direct was undertaken. Studies related to multidisciplinary care or general neurological care in ALS patients that assessed survival and quality of life and were published in the period up to and including January 2020 were included. A total of 1192 studies were initially identified, but only 6 were included. All studies that investigated survival showed and advantage of MDC over NC, and this benefit was even greater for bulbar onset patients. A meta-analysis was performed and showed a mean difference of 141.67 (CI 95%, 61.48 to 221.86), indicating that patients who received MDC had longer survival than those who underwent NC (p = 0.0005). Concerning QoL, only one study found better mental health scores related to QoL for patients under MDC. Multidisciplinary care is more effective than general neurology care at improving survival of patients with ALS, but only improves mental health outcomes related to quality of life of these patients.

多学科护理（MDC）是肌萎缩侧索硬化症（ALS）症状管理的最推荐方法，但有关其对ALS患者生存和生活质量（QoL）的有效性的证据相互矛盾。我们进行了系统的评估，以确定与一般神经科护理相比，多学科护理对ALS患者的生存和生活质量的影响。进行了全面的文献搜索，使用Scopus，MEDLINE-PubMed，Cochrane，Web of Science，PEDro和Science Direct。纳入了与ALS患者的多学科护理或一般神经科护理有关的研究，这些研究评估了生存和生活质量，并在2020年1月（含）之前发表。最初确定了1192项研究，但仅包括6项。所有研究生存率的研究均显示了MDC优于NC的优势，而延髓发作患者的这种优势甚至更大。进行荟萃分析，发现平均差异为141.67（CI 95％，从61.48到221.86），这表明接受MDC的患者比接受NC的患者存活时间更长（p = 0.0005）。关于QoL，只有一项研究发现MDC下患者的QoL相关的心理健康评分更高。多学科护理比普通神经科护理更有效地改善ALS患者的生存率，但只能改善与这些患者生活质量有关的心理健康结果。