Antimicrobial resistance is a major health issue inducing the inefficiency of antimicrobial drugs. Indeed, pathogenic microorganisms become resistant when frequently exposed to antimicrobial drugs. In particular, when bacteria are attached to a surface and expand as a biofilm, they become more resistant to antimicrobials because single or multiple bacterial species are embedded in a slimy extracellular polymeric substance that acts like a shield. Biofilms often contaminate medical devices and food industrial equipment, thus leading to infections and food spoilage. Here, we review the basics of biofilm development from a planktonic bacterium; signaling in biofilm and relationship with antimicrobial resistance; biofilm control and destruction strategies using quorum sensing inhibitors, ultrasound, acidic electrolyzed water, and enzymatic and combination killing; and emerging approaches, such as bacteriophage-mediated disruption and antimicrobial peptides to control bacterial biofilms.

抗菌素耐药性是导致抗菌药物效率低下的主要健康问题。确实，当经常暴露于抗微生物药物时，病原微生物会产生抗药性。尤其是，当细菌附着在表面并以生物膜的形式扩展时，由于单个或多个细菌物种被嵌入到像盾一样起作用的粘稠的细胞外聚合物中，因此它们对抗菌剂的抵抗力变得更强。生物膜经常污染医疗设备和食品工业设备，从而导致感染和食品变质。在这里，我们回顾了浮游细菌生物膜发展的基础。生物膜中的信号传导及其与抗菌素耐药性的关系；使用群体感应抑制剂，超声，酸性电解水控制和破坏生物膜的策略，酶和组合杀灭；新兴的方法，例如噬菌体介导的破坏和控制细菌生物膜的抗菌肽。