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Intergenerational transmission of longevity is not affected by other familial factors: evidence from 16,905 Dutch families from Zeeland, 1812-1962
The History of the Family ( IF 1.190 ) Pub Date : 2020-07-02 , DOI: 10.1080/1081602x.2020.1740763
R. J. Mourits 1, 2 , N. van den Berg 3 , M. Rodríguez-Girondo 3 , K. Mandemakers 4, 5 , P. E. Slagboom 3 , M. Beekman 3 , A. A. P. O. Janssens 1, 6
Affiliation  

ABSTRACT Studies have shown that long-lived individuals seem to pass their survival advantage on to their offspring. Offspring of long-lived parents had a lifelong survival advantage over individuals without long-lived parents, making them more likely to become long-lived themselves. We test whether the survival advantage enjoyed by offspring of long-lived individuals is explained by environmental factors. 101,577 individuals from 16,905 families in the 1812–1886 Zeeland cohort were followed over time. To prevent that certain families were overrepresented in our data, disjoint family trees were selected. Offspring was included if the age at death of both parents was known. Our analyses show that multiple familial resources are associated with survival within the first 5 years of life, with stronger maternal than paternal effects. However, between ages 5 and 100 both parents contribute equally to offspring’s survival chances. After age 5, offspring of long-lived fathers and long-lived mothers had a 16-19% lower chance of dying at any given point in time than individuals without long-lived parents. This survival advantage is most likely genetic in nature, as it could not be explained by other, tested familial resources and is transmitted equally by fathers and mothers.

中文翻译:

长寿的代际传播不受其他家族因素的影响:来自Zeeland的16,905个荷兰家庭的证据,1812-1962年

摘要研究表明,长寿的个体似乎将生存优势转移给了后代。与没有长寿父母的人相比,长寿父母的后代具有终生生存优势,这使他们更有可能成为长寿自己。我们测试环境因素是否可以解释长寿个体的后代享有的生存优势。随着时间的推移,在1812年至1886年的Zeeland队列中,来自16905个家庭的101577个人得到了追踪。为了防止某些家庭在我们的数据中被过多代表,我们选择了不相交的家谱。如果已知父母双方的死亡年龄,则包括后代。我们的分析表明,多种家族资源与生命的头5年内的生存相关,其母性比父性强。然而,在5岁到100岁之间,父母双方均对后代的生存机会做出了同样的贡献。5岁以后,长寿父亲和长寿母亲的后代在任何给定时间点的死亡几率要比没有长寿父母的个体低16-19%。这种生存优势很可能是遗传性质的,因为无法通过其他经过测试的家族资源加以解释,并且由父亲和母亲平等地传播。
更新日期:2020-07-02
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