OBJECTIVE Despite preliminary evidence of unique acute cognitive and psychopharmacological changes attributable to combined alcohol and cannabis use, few studies have investigated more chronic effects of same-day co-use, particularly during neurodevelopmentally sensitive periods. Therefore, relationships between past-month binge alcohol and cannabis co-use and cognitive functioning were examined in adolescents and young adults. METHOD Data from the Imaging Data in Emerging Adults with Addiction (IDEAA) Consortium were used to assess cognitive functioning in emerging adults with a large range of substance use (n = 232; 15-26 years old) who were abstinent for at least 3 weeks. Multiple regressions assessed cognitive functioning by past-month binge episodes, cannabis use episodes, and same-day co-use, controlling for covariates (e.g., study site, sex, age). RESULTS After correcting for multiple comparisons, more past-month co-use episodes were related to decreased Ruff 2&7 selective attention accuracy (p = .036). Sex significantly covaried with California Verbal Learning Test-Second Edition initial learning. CONCLUSIONS Although few significant relationships were found and effect sizes are modest, the persistence of an effect on attention despite a period of sustained abstinence highlights the need to carefully investigate patterns of substance use and potential independent and interactive effects on the developing brain.

中文翻译：

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与戒酒的青少年和年轻人共同使用的酗酒和大麻有关的认知功能

目的尽管有初步的证据表明，酒精和大麻的联合使用可引起独特的急性认知和心理药理学改变，但很少有研究调查同日共同使用的更多慢性影响，尤其是在神经发育敏感时期。因此，在青少年和年轻人中检查了过去一个月的暴饮酒和大麻的共同使用与认知功能之间的关系。方法使用来自成年成瘾者（IDEAA）联合会成像数据的数据评估禁食至少3周，使用物质范围广泛（n = 232； 15-26岁）的成年成年人的认知功能。多元回归分析通过过去一个月的暴饮暴食发作，大麻使用发作和当日共同使用来评估认知功能，并控制协变量（例如研究地点，性别，年龄）。结果在校正了多个比较之后，过去一个月的更多共同使用情节与Ruff 2＆7选择性注意准确性的降低有关（p = .036）。性别与加州语言学习测验第二版的初始学习显着相关。结论尽管发现了很少的显着关系并且效应大小适中，但尽管持续一段时间禁欲，效应的持续存在也凸显了需要仔细研究药物使用的模式以及对发育中的大脑的潜在独立和交互作用的重要性。