Buprenorphine's high-binding affinity as a partial µ-opioid agonist displaces preexisting full agonists causing precipitated withdrawal, which requires most individuals starting buprenorphine to endure moderate withdrawal prior to induction to avoid precipitated withdrawal. A novel approach called microinduction has emerged to remove this prerequisite. Our aim is to review the literature on these alternative approaches.

中文翻译：

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丁丙诺啡/纳洛酮的微量诱导：文献综述

丁丙诺啡作为部分 μ-阿片类激动剂的高结合亲和力取代了预先存在的完全激动剂，从而导致突然戒断，这需要大多数开始使用丁丙诺啡的人在诱导前耐受适度戒断，以避免突然戒断。出现了一种称为微诱导的新方法来消除这一先决条件。我们的目的是回顾有关这些替代方法的文献。