Branched poly(N-isopropylacrylamide) was functionalized with Amphotericin B (AmB) at the chain ends to produce an antifungal material. The polymer showed antifungal properties against AmB-sensitive strains of Candida albicans, Fusarium keratoplasticum and Aspergillus flavus (minimal inhibitory concentration ranged from 5 to 500 µg ml⁻¹) but was not effective against an AmB resistant strain of C. albicans nor against Candida tropicalis. The polymer end groups bound to the AmB target, ergosterol, and the fluorescence spectrum of a dye used as a solvatochromic probe, Nile red, was blue shifted indicating that segments of the polymer became desolvated on binding. The polymer was less toxic to corneal and renal epithelial cells and explanted corneal tissue than the free drug. Also, the polymer did not induce reactive oxygen species release from peripheral blood mononuclear cells, nor did it cause a substantial release of the proinflammatory cytokines, tumour necrosis factor-α and interleukin-1β (at 0.5 mg ml⁻¹).

支化聚（ñ -异丙基丙烯酰胺）的混合物在链端用两性霉素B（AMB）官能化，以产生的抗真菌材料。该聚合物对白色念珠菌，圆锥形镰刀菌和黄曲霉的AmB敏感菌株具有抗真菌特性（最低抑制浓度为5至500 µg ml ^-1），但对白色念珠菌的抗AmB菌株或热带念珠菌无效。。与AmB靶麦角固醇结合的聚合物端基和用作溶剂化变色探针的染料的荧光光谱（尼罗河红）呈蓝移，​​表明聚合物的链段在结合时被去溶剂化。与游离药物相比，该聚合物对角膜和肾上皮细胞以及移植的角膜组织的毒性较小。另外，聚合物不诱导反应性氧物质从外周血单核细胞释放，也没有导致促炎细胞因子的大量释放，肿瘤坏死因子α和白细胞介素1 β（0.5毫克毫升^-1）。