Supramolecular biopolymers (SBPs) are those polymeric units derived from macromolecules that can assemble with each other by noncovalent interactions. Macromolecular structures are commonly found in living systems such as proteins, DNA/RNA, and polysaccharides. Bioorganic chemistry allows the generation of sequence-specific supramolecular units like SBPs that can be tailored for novel applications in tissue engineering (TE). SBPs hold advantages over other conventional polymers previously used for TE; these materials can be easily functionalized; they are self-healing, biodegradable, stimuli-responsive, and nonimmunogenic. These characteristics are vital for the further development of current trends in TE, such as the use of pluripotent cells for organoid generation, cell-free scaffolds for tissue regeneration, patient-derived organ models, and controlled delivery systems of small molecules. In this review, we will analyse the 3 subtypes of SBPs: peptide-, nucleic acid-, and oligosaccharide-derived. Then, we will discuss the role that SBPs will be playing in TE as dynamic scaffolds, therapeutic scaffolds, and bioinks. Finally, we will describe possible outlooks of SBPs for TE.

中文翻译：

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用于组织工程的超分子生物聚合物

超分子生物聚合物（SBP）是衍生自大分子的那些聚合单元，它们可以通过非共价相互作用相互组装。大分子结构通常存在于生命系统中，例如蛋白质，DNA / RNA和多糖。生物有机化学可以生成序列特异性的超分子单位，例如SBP，可以针对组织工程学（TE）中的新应用进行定制。SBP与先前用于TE的其他常规聚合物相比具有优势。这些材料可以很容易地功能化；它们具有自我修复，可生物降解，刺激反应和非免疫原性的作用。这些特性对于TE的当前趋势的进一步发展至关重要，例如将多能细胞用于类器官的产生，将无细胞支架用于组织再生，患者来源的器官模型，和小分子的受控传递系统。在这篇综述中，我们将分析SBP的3个亚型：肽，核酸和寡糖衍生。然后，我们将讨论SBP在TE中作为动态支架，治疗支架和生物墨水的作用。最后，我们将描述TE的SBP的可能前景。