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Regulator of Chromosome Condensation 2 Modulates Cell Cycle Progression, Tumorigenesis, and Therapeutic Resistance
Frontiers in Molecular Biosciences ( IF 5 ) Pub Date : 2020-12-08 , DOI: 10.3389/fmolb.2020.620973
Kun Guo , Cheng Zhao , Bin Lang , Huiqin Wang , Hang Zheng , Feng Zhang

Accurate regulation of cell cycle is important for normal tissue development and homeostasis. RCC2 (Regulator of Chromosome Condensation 2) play a role as chromosomal passenger complex (CPC) implicated in all cell cycle phases. RCC2 was initially identified as Ran guanine exchange factor (GEF) for small G proteins. Therefore, RCC2 plays a key role in oncogenesis of most cancers. RCC2 is implicated in Colorectal Cancer (CRC), Lung Adenocarcinoma (LUAD), breast cancer, and ovarian cancer. Expression level of RCC2 protein determines regulation of tumor cell proliferation, invasion, metastasis, and radio-chemotherapeutic resistance. In this review, we explored proteins that interact with RCC2 to modulate tumor development and cancer therapeutic resistance by regulation of cell cycle process through various signaling pathways.



中文翻译:

染色体浓缩调节剂2调节细胞周期进程,肿瘤发生和治疗抗性。

准确调节细胞周期对于正常组织发育和体内平衡很重要。RCC2(染色体浓缩物2的调节剂)在所有细胞周期阶段中均起着染色体乘客复合物(CPC)的作用。RCC2最初被确定为小G蛋白的Ran鸟嘌呤交换因子(GEF)。因此,RCC2在大多数癌症的肿瘤发生中起关键作用。RCC2与大肠癌(CRC),肺腺癌(LUAD),乳腺癌和卵巢癌有关。RCC2蛋白的表达水平决定了肿瘤细胞增殖,侵袭,转移和放化疗耐药性的调控。在这篇综述中,我们探索了与RCC2相互作用的蛋白,通过各种信号通路调节细胞周期过程,从而调节肿瘤的发展和癌症的治疗抗性。

更新日期:2021-01-13
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