Liver metastases lead to resistance to immunotherapy through the ‘siphoning’ of tumor antigen–specific CD8+ T cells into the liver, which results in a systemic ‘immune desert’ incapable of controlling tumor burden.

中文翻译：

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肝转移抑制免疫治疗功效

肝转移通过将肿瘤抗原特异性CD8 + T细胞“虹吸”到肝脏中而导致对免疫疗法的抵抗，从而导致无法控制肿瘤负担的全身性“免疫沙漠”。