当前位置: X-MOL 学术Chronobiol. Int. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Rest-activity rhythms in emerging adults: implications for cardiometabolic health
Chronobiology International ( IF 2.8 ) Pub Date : 2021-01-13
Elissa K. Hoopes, Melissa A. Witman, Michele N. D’Agata, Felicia R. Berube, Benjamin Brewer, Susan K. Malone, Michael A. Grandner, Freda Patterson

ABSTRACT

Emerging adulthood (18–25 years) represents a window of opportunity to modify the trajectory of cardiometabolic disease risk into older adulthood. Not known is the extent to which rest-activity rhythms (RAR) may be related to biomarkers of cardiometabolic health in this population. In this cross-sectional, observational study, 52 healthy emerging adults wore wrist accelerometers (14 consecutive days; 24 h/day) for assessment of nonparametric RAR metrics, including interdaily stability (IS; day-to-day RAR consistency), intradaily variability (IV; within-day RAR fragmentation), and relative amplitude (RA; robustness of RAR), as well as autocorrelation (correlation of rest/activity levels at 24-h lag-times). Cardiometabolic biomarkers, including body mass index (BMI), body fat percentage, blood pressure (BP), fasting lipids, glucose, and C-reactive protein (CRP) were assessed. Additional measures including physical activity, sleep duration, and habitual caffeine and alcohol consumption were also evaluated. A series of multivariable regression models of cardiometabolic biomarkers were used to quantify associations with RAR metrics. On average, participants were 20 ± 1 years of age (21 males, 31 females), non-obese, and non-hypertensive. All were nonsmokers and free of major diseases or conditions. In separate models, which adjusted for sex, BMI, moderate-vigorous physical activity, sleep duration, caffeine, and alcohol consumption, IS was inversely associated with total cholesterol (p ≤ 0.01) and non-HDL cholesterol (p < .05), IV was positively associated with CRP (p < .05), and autocorrelation was inversely associated with total cholesterol (p < .05) and CRP (p < .05). Conversely, associations between RA and cardiometabolic biomarkers were nonsignificant after adjustment for BMI, alcohol, and caffeine consumption. In conclusion, RAR metrics, namely, a higher IS, lower IV, and higher autocorrelation, emerged as novel biomarkers associated with more favorable indices of cardiometabolic health in this sample of apparently healthy emerging adults.



中文翻译:

新兴成年人的休息活动节律:对心脏代谢健康的影响

摘要

新兴的成年(18-25岁)代表了一个机会窗口,可以改变成年后的心脏代谢疾病风险轨迹。目前尚不清楚静息节律(RAR)与该人群心脏代谢健康生物标志物相关的程度。在这项横断面的观察性研究中,有52名健康的新兴成年人戴着手腕加速度计(连续14天;每天24小时)来评估非参数RAR指标,包括日间稳定性(IS;日常RAR一致性),日内变异性(IV;一天之内的RAR碎片化),相对幅度(RA; RAR的鲁棒性),以及自相关(在24小时滞后时间,休息/活动水平的相关性)。心脏代谢生物标志物,包括体重指数(BMI),体脂百分比,血压(BP),空腹血脂,葡萄糖,评估C反应蛋白(CRP)。还评估了其他措施,包括体育锻炼,睡眠时间以及习惯性咖啡因和酒精摄入量。一系列代谢生物标志物的多变量回归模型用于量化与RAR指标的关联。平均而言,参与者年龄为20±1岁(男性21例,女性31例),非肥胖和非高血压。他们都是不吸烟者,没有重大疾病或状况。在针对性别,BMI,中等强度的体育锻炼,睡眠时间,咖啡因和酒精消耗进行调整的单独模型中,IS与总胆固醇(p≤0.01)和非HDL胆固醇(一系列代谢生物标志物的多变量回归模型用于量化与RAR指标的关联。平均而言,参与者年龄为20±1岁(男性21例,女性31例),非肥胖和非高血压。他们都是不吸烟者,没有重大疾病或状况。在针对性别,BMI,中等强度的体育锻炼,睡眠时间,咖啡因和酒精消耗进行调整的单独模型中,IS与总胆固醇(p≤0.01)和非HDL胆固醇(一系列代谢生物标志物的多变量回归模型用于量化与RAR指标的关联。平均而言,参与者年龄为20±1岁(男性21例,女性31例),非肥胖和非高血压。他们都是不吸烟者,没有重大疾病或状况。在针对性别,BMI,中等强度的体育锻炼,睡眠时间,咖啡因和酒精消耗进行调整的单独模型中,IS与总胆固醇(p≤0.01)和非HDL胆固醇(p <.05),IV与CRP正相关(p <.05),自相关与总胆固醇(p <.05)和CRP(p <.05)呈负相关。相反,在调整了BMI,酒精和咖啡因的摄入量之后,RA与心脏代谢生物标志物之间的关联不显着。总而言之,RAR指标,即更高的IS,更低的IV和更高的自相关性,在与这些看起来健康的新兴成年人的心脏代谢健康指数相关的新型生物标志物中崭露头角。

更新日期:2021-01-13
down
wechat
bug