Abstract

Phytochemical investigation of a new plant, Capparis dongvanensis (Sy, B. H. Quang & D. V. Hai) of the Capparaceae family was carried out and identified two new polycyclic compounds and twelve known compounds. Among them, compounds 3 and 7 are two new polycyclic compounds, while twelve known compounds are stigmasterol (1), β-sitosterol (2), nonadecan-1-ol (4), nonacosan-1-ol (5), nonadecyl nonadecanoate (6), tetracontane (8), benzoic acid (9), salicylic acid (10), tryptophan (11), glycine (12), berberine (13), and β-sitosterol 3-O-β-D-glucopyranoside (14). The chemical structures of the isolated compounds were confirmed based on NMR spectral and mass spectrometry (MS) data. Moreover, we also elucidated the chemotaxonomic significance of these isolated compounds. In the end, preliminary bioactivity assessment of ethanolic and ethyl acetate extracts of Capparis dongvanensis leaves indicated that both extracts exhibited inhibitory activities on five cancer cell lines and alpha-glucosidase enzyme.

摘要

进行了Capparaceae家族的新植物Capparis dongvanensis（Sy，BH Quang和DV Hai）的植物化学研究，并确定了两种新的多环化合物和十二种已知化合物。其中，化合物3和7是两个新的多环化合物，而十二种已知化合物是豆甾醇（1），β-谷甾醇（2），壬基-1-醇（4），壬二糖-1-醇（5），壬基壬二酸酯（6），四烷（8），苯甲酸（9），水杨酸（10），色氨酸（11），甘氨酸（12），小ber碱（13）和β-谷甾醇3-O -β -D-吡喃葡萄糖苷（14）。基于NMR光谱和质谱（MS）数据确认了分离的化合物的化学结构。此外，我们还阐明了这些分离化合物的化学分类学意义。最后，初步的生物活性评估，对Capcapis dongvanensis叶片的乙醇和乙酸乙酯提取物都显示出对五种癌细胞系和α-葡萄糖苷酶的抑制活性。