Objective The aim of this study was to determine the prevalence of acute traumatic coagulopathy (ATC) and identify associated clinical and laboratory parameters including rotational thromboelastometry.

Study Design Dogs presenting within 6 hours after trauma were allocated to the ATC or non-ATC group based on thromboelastometry analysis (ex-tem S, in-tem S, fib-tem S). ATC was defined as ≥2 hypocoagulable parameters in 1 profile and ≥ 1 hypocoagulable parameter in an additional profile. Parameters used were ex-tem and in-tem clotting time (CT), clot formation time (CFT), maximum clot firmness (MCF), maximum lysis and fib-tem MCF. Clinical and laboratory parameters at presentation, animal trauma triage (ATT) score, transfusion requirement and outcome were compared. Logistic regression was used to identify independent factors associated with ATC.

Results Eleven of 33 dogs presented with ATC and showed ex-tem CT and CFT prolongation and reduced MCF amplitude in all profiles (all p < 0.001). pH (p = 0.043) and potassium concentration (p = 0.022) were significantly lower and bleeding (p = 0.027) and plasma transfusions (p = 0.001) more common in dogs with ATC. Time after trauma (p = 0.040) and Animal Trauma Triage score (p = 0.038, including haematocrit as confounding factor) were associated with the presence of ATC.

Conclusion Acute traumatic coagulopathy is more common in traumatized dogs than previously reported. Acute traumatic coagulopathy was associated with acidosis, Animal trauma triage score, time after trauma and higher transfusion needs. Coagulation abnormalities include ex-tem CT and CFT prolongations and decreased clot strength.

目的 本研究的目的是确定急性创伤性凝血病 (ATC) 的患病率，并确定相关的临床和实验室参数，包括旋转血栓弹力图。

研究设计 基于血栓弹力图分析（ex-tem S、in-tem S、fib-tem S），将在创伤后 6 小时内出现的狗分配到 ATC 或非 ATC 组。ATC 被定义为 1 个配置文件中 ≥ 2 个低凝参数和一个附加配置文件中 ≥ 1 个低凝参数。使用的参数是体外和体内凝血时间 (CT)、凝块形成时间 (CFT)、最大凝块牢固度 (MCF)、最大裂解和 fib-tem MCF。比较了就诊时的临床和实验室参数、动物创伤分类 (ATT) 评分、输血需求和结果。Logistic 回归用于识别与 ATC 相关的独立因素。

结果 33 只狗中有 11 只出现 ATC，并在所有曲线中显示出体外 CT 和 CFT 延长以及 MCF 幅度降低（所有p < 0.001）。pH ( p = 0.043 ) 和钾浓度 ( p =  0.022) 显着降低，出血 ( p = 0.027 ) 和血浆输注(p =  0.001 )在患有 ATC 的狗中更为常见。创伤后时间 ( p =  0.040) 和动物创伤分类评分 ( p =  0.038，包括血细胞比容作为混杂因素) 与 ATC 的存在相关。

结论 急性外伤性凝血病在外伤犬中比以前报道的更常见。急性创伤性凝血病与酸中毒、动物创伤分类评分、创伤后时间和更高的输血需求有关。凝血异常包括体外 CT 和 CFT 延长以及凝块强度降低。