Background

Tigecycline is an antibiotic that well tolerated for treating complicated infections. It has received attention as an anti-cancer agent and expected to solve two major obstacles, sides effects that accompany chemotherapy and drug resistance, in the breast cancer treatment. However, previous studies reported that the levels in the blood are typically low of tigecycline, so higher doses are needed to treat cancer, that may increase the risk of side effects. To achieve better anti-cancer effects for tigecycline, we need to find a novel adjunct agent.

Methods

In this study, we used different concentration of pyrvinium pamoate combined with tigecycline to treat cell. And assess the effect of two drugs in inhibit cell proliferation, induce cell autophagy, or increase cell apoptosis to evaluate the consequent of combined therapy.

Results

We observed that after the combined therapy, the cell cycle arrest at G1/s phase, the level of p21 increased, but decreased the levels of CDK2. Others, two drugs via different mechanisms to inhibit cancer cell proliferation and with selective cytotoxic to different cell lines. That could enhance the effect of breast cancer treatment.

Conclusion

Combining low dose of tigecycline use with pyrvinium pamoate is a novel approach for breast cancer treatment. Appropriate combined therapy in breast cancer is recommended to improve outcomes. Other problems like drug resistance occur in patients or the microbes surrounding breast tissues would confer susceptibility to cancers then influence the effectiveness of treatment, which could be improved through combined therapy.

中文翻译：

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癌症作为一种传染病：使用替加环素和双羟萘酸吡啶组合的另一种治疗选择——乳腺癌的一个例子

背景

替加环素是一种对治疗复杂感染具有良好耐受性的抗生素。它作为一种抗癌剂受到关注，并有望解决乳腺癌治疗中伴随化疗的副作用和耐药性这两个主要障碍。然而，先前的研究报告称，血液中的替加环素水平通常较低，因此需要更高剂量来治疗癌症，这可能会增加副作用的风险。为了使替加环素达到更好的抗癌效果，我们需要寻找一种新型的辅助药物。

方法

在本研究中，我们使用不同浓度的双羟萘酸吡啶联合替加环素处理细胞。并评估两种药物在抑制细胞增殖、诱导细胞自噬或增加细胞凋亡方面的作用，以评价联合治疗的效果。

结果

我们观察到联合治疗后，细胞周期停滞在G1/s期，p21水平升高，而CDK2水平降低。其他的，两种药物通过不同的机制抑制癌细胞增殖并对不同的细胞系具有选择性的细胞毒作用。这可以增强乳腺癌治疗的效果。

结论

将低剂量的替加环素与双羟萘酸吡啶结合使用是一种治疗乳腺癌的新方法。建议对乳腺癌进行适当的联合治疗以改善预后。其他问题如耐药性发生在患者身上或乳房组织周围的微生物会导致对癌症的易感性，然后影响治疗的有效性，这可以通过联合治疗来改善。