Considerable researches implicate that the circadian clock regulates the responsive rhythms of organs and sets the orderly aging process of cells indirectly. It influences an array of diverse biological process including intestinal flora, peripheral inflammatory responses, and redox homeostasis. People with sleep disoders and other kinds of circadian disruptions are prone to have vascular aging earlier. Meanwhile, those people are always faced with chronic vascular inflammation. It has not been elucidated that the specific mechanism of the interaction between the circadian system and early vascular aging. To explore the biphasic relationship between vascular aging and the circadian system, we summarize what is linking circadian clock with early vascular aging through four major prospect: inflammatory process, oxidative stress response, intestinal flora, and cellular senescence. Meanwhile, we discuss the hypothesis that the deterioration of circadian rhythms may exacerbate the process of early vascular aging, leading to the cardiovascular diseases. It will help us to provide new ideas for understanding the process of vascular aging and exploring the possible ways to design personalized chronotherapies.

大量研究表明，生物钟调节器官的响应节奏并间接设定细胞的有序衰老过程。它会影响多种多样的生物过程，包括肠道菌群，外周炎症反应和氧化还原稳态。患有睡眠障碍和其他昼夜节律紊乱的人更容易出现血管老化。同时，这些人总是面临慢性血管炎症。尚未阐明昼夜节律系统与早期血管衰老之间相互作用的具体机制。为探讨血管衰老与昼夜节律系统之间的两相关系，我们通过以下四个主要方面总结了昼夜节律与早期血管衰老之间的联系：炎症过程，氧化应激反应，肠道菌群和细胞衰老。同时，我们讨论了昼夜节律恶化可能加剧早期血管衰老过程并导致心血管疾病的假说。这将帮助我们提供新的思路，以了解血管衰老的过程，并探索设计个性化计时疗法的可能方法。