Abstract

In this study, antibacterial Ag element added to synthesis of porous Ti–20Nb–5Ag (wt%) alloy using powder metallurgy space holder route. The microstructural, mechanical property, surface bioactivity and cytotoxicity behavior of porous Ti–20Nb–5Ag alloy have been investigated. The developed porous alloy obtained the porosities ranging from 22.5 to 68%. The porous sample having a porosity of about 43% is found to be in the optimum condition, which possess a modulus of about 5.8 GPa with an excellent compressive strength about 205 MPa. XRD result shows that the formation of small amount of α-Ti, β-Ti, along with α״ martensite and Ti₂Ag are key phase constituents of sintered porous Ti–20Nb–5Ag alloys. The compression strength and elastic modulus of the sintered alloys were showed that decreased with increase of porosity. Surface bioactivity result revealed that the significant formation of hydroxyapatite on the alkali-heat treated (5 M NaOH) porous Ti–20Nb–5Ag alloy which is found after the in vitro test in SBF. Further, the cell viability test was conducted on as-synthesized porous Ti–20Nb–5Ag alloy for 1, 4, and 7 days using MG-63 human osteoblast cells and result shows an excellent cell proliferation, and the cytotoxicity test confirms the non-toxic nature of the porous alloy which is very much suitable for implant application.

Graphic Abstract

中文翻译：

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生物医学多孔Ti-20Nb-5Ag合金的开发与表征：微观结构，力学性能，表面生物活性和细胞活力研究

摘要

在这项研究中，使用粉末冶金空间保持器路线向多孔Ti-20Nb-5Ag（wt％）合金的合成中添加了抗菌Ag元素。研究了多孔Ti-20Nb-5Ag合金的微观结构，力学性能，表面生物活性和细胞毒性。所开发的多孔合金获得的孔隙率为22.5％至68％。发现具有约43％的孔隙率的多孔样品处于最佳条件，其具有约5.8GPa的模量和约205MPa的优异的抗压强度。XRD结果表明，与α-马氏体和Ti ₂一起形成少量的α-Ti，β-Ti银是烧结多孔Ti-20Nb-5Ag合金的关键相成分。结果表明，烧结合金的抗压强度和弹性模量随孔隙率的增加而降低。表面生物活性结果表明，经碱热处理（5 M NaOH）的多孔Ti-20Nb-5Ag合金上明显形成了羟基磷灰石，这是在SBF的体外试验后发现的。此外，使用MG-63人成骨细胞对合成后的多孔Ti-20Nb-5Ag合金进行了1、4和7天的细胞活力测试，结果显示了优异的细胞增殖能力，并且细胞毒性测试证实了非多孔合金的毒性，非常适合植入应用。

图形摘要