A pathologically formed blood clot or thrombus is central to major cardiovascular diseases like heart attack and stroke. Detailed quantitative evaluation of flow and flow-mediated transport processes in the thrombus neighborhood within large artery hemodynamics is crucial for understanding disease progression and assessing treatment efficacy. This, however, remains a challenging task owing to the complexity of pulsatile viscous flow interactions with arbitrary shape and heterogeneous microstructure of realistic thrombi. Here, we address this challenge by conducting a systematic parametric simulation-based study on characterizing unsteady hemodynamics and flow-mediated transport in the neighborhood of an arterial thrombus. We use a hybrid particle—continuum-based finite element approach to handle arbitrary thrombus shape and microstructural variations. Results from a cohort of 50 different unsteady flow scenarios are presented, including unsteady vortical structures, pressure gradient across the thrombus boundary, finite time Lyapunov exponents, and dynamic coherent structures that organize advective transport. We clearly illustrate the combined influence of three key parameters—thrombus shape, microstructure, and extent of wall disease—in terms of: (a) determining hemodynamic features in the thrombus neighborhood and (b) governing the balance between advection, permeation, and diffusion to regulate transport processes in the thrombus neighborhood.

病理形成的血凝块或血栓是心脏病发作和中风等主要心血管疾病的核心。大动脉血流动力学中血栓附近的血流和血流介导的转运过程的详细定量评估对于了解疾病进展和评估治疗效果至关重要。然而，由于脉动粘性流动与现实血栓的任意形状和异质微观结构相互作用的复杂性，这仍然是一项具有挑战性的任务。在这里，我们通过对动脉血栓附近的不稳定血流动力学和流动介导的运输进行表征的系统参数模拟研究来解决这一挑战。我们使用混合粒子-基于连续介质的有限元方法来处理任意血栓形状和微观结构变化。展示了 50 种不同非定常流动场景的结果，包括非定常涡结构、跨血栓边界的压力梯度、有限时间 Lyapunov 指数和组织平流传输的动态相干结构。我们清楚地说明了三个关键参数——血栓形状、微观结构和壁病程度——的综合影响：(a) 确定血栓附近的血流动力学特征和 (b) 控制平流、渗透和扩散之间的平衡调节血栓附近的运输过程。跨血栓边界的压力梯度、有限时间李雅普诺夫指数和组织对流传输的动态相干结构。我们清楚地说明了三个关键参数——血栓形状、微观结构和壁病程度——的综合影响：(a) 确定血栓附近的血流动力学特征和 (b) 控制平流、渗透和扩散之间的平衡调节血栓附近的运输过程。跨血栓边界的压力梯度、有限时间李雅普诺夫指数和组织对流运输的动态相干结构。我们清楚地说明了三个关键参数——血栓形状、微观结构和壁病程度——的综合影响：(a) 确定血栓附近的血流动力学特征和 (b) 控制平流、渗透和扩散之间的平衡调节血栓附近的运输过程。