We examine two types of information loss function encountered in optical neural recording—the uncertainty of neural states encoding an external stimulus and the incompleteness of information that laser-excited fluorescence can read out from these neural states. We show that, even though these uncertainties are of distinctly different nature, they can be treated on an equal footing against the Fisher information metric, revealing the fundamental information limits inherent in optical neural recording.

中文翻译：

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从光学神经反应读数解析神经状态

我们研究了光学神经记录中遇到的两种信息丢失函数：编码外部刺激的神经状态的不确定性以及激光激发的荧光可以从这些神经状态中读出的信息的不完整性。我们表明，即使这些不确定性具有截然不同的性质，也可以将它们与Fisher信息量度按相等的原则对待，从而揭示光学神经记录固有的基本信息限制。