Oral mesenchymal stem cells (MSCs) and their secretomes are considered important factors in the field of medical tissue engineering and cell free biotherapy due to their ease of access, differentiation potential, and successful therapeutic outcomes. Extracellular vesicles (EVs) and the conditioned medium (CM) from MSCs are gaining more attraction as an alternative to cell-based therapies due to the less ethical issues involved, and their easier acquisition, preservation, long term storage, sterilization, and packaging. Bone and periodontal regenerative ability of EVs and CM have been the focus of some recent studies. In this review, we looked through currently available literature regarding MSCs’ EVs or conditioned medium and their general characteristics, function, and regenerative potentials. We will also review the novel applications in regenerating bone and periodontal defects.

中文翻译：

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骨和牙周再生中的细胞外囊泡：当前和潜在的治疗应用

口服间充质干细胞（MSCs）及其分泌组被认为是医学组织工程和无细胞生物治疗领域的重要因素，因为它们易于获取，具有分化潜能和成功的治疗效果。由于涉及的伦理问题较少，并且它们更易于获取，保存，长期保存，灭菌和包装，因此来自MSC的细胞外囊泡（EV）和条件培养基（CM）作为基于细胞的疗法的替代品正变得越来越有吸引力。EV和CM的骨和牙周再生能力已成为一些近期研究的重点。在这篇综述中，我们浏览了有关MSC的EV或条件培养基及其一般特征，功能和再生潜力的现有文献。