Because of their roles as potential risk factors, we evaluated whether obstructive sleep apnea (OSA) severity interacts with interleukin-6 (IL-6) in predicting incident dementia of the Alzheimer’s type (DAT). In 269 dementia-free participants, IL-6 and the apnea-hypopnea index (AHI) were measured at baseline and incident DAT was surveilled for up to 22.8 years. Cox models revealed a significant interaction: In the lowest IL-6 quartile only, a higher AHI was associated with an elevated risk of DAT. The association between OSA severity and incident DAT might be especially apparent in the absence of inflammation or absence of potential benefits from IL-6.

中文翻译：

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在预测阿尔茨海默病痴呆症时，白细胞介素 6 与睡眠呼吸暂停严重程度相互作用

由于它们作为潜在危险因素的作用，我们评估了阻塞性睡眠呼吸暂停 (OSA) 的严重程度是否与白细胞介素 6 (IL-6) 相互作用以预测阿尔茨海默病型痴呆 (DAT)。在 269 名无痴呆的参与者中，IL-6 和呼吸暂停低通气指数 (AHI) 在基线时进行了测量，并对事件 DAT 进行了长达 22.8 年的监测。Cox 模型揭示了显着的交互作用：仅在最低的 IL-6 四分位数中，较高的 AHI 与 DAT 风险升高相关。在没有炎症或 IL-6 没有潜在益处的情况下，OSA 严重程度与事件 DAT 之间的关联可能尤其明显。