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Lateralized Deficits in Motor, Sensory, and Olfactory Domains in Dementia
Journal of Alzheimer’s Disease ( IF 4 ) Pub Date : 2021-01-11 , DOI: 10.3233/jad-201216
Ethan Schonfeld 1 , Elan Schonfeld 2 , Casey Aman 3 , Navroop Gill 3 , Dami Kim 3 , Sydney Rabin 3 , Bushraa Shamshuddin 3 , Lloyd Sealey 3 , Ricardo Gabriel Senno 3
Affiliation  

Background:There exist functional deficits in motor, sensory, and olfactory abilities in dementias. Measures of these deficits have been discussed as potential clinical markers. Objective:We measured the deficit of motor, sensory, and olfactory functions on both the left and right body side, to study potential body lateralizations. Methods:This IRB-approved study (N = 84) performed left/right clinical tests of gross motor (dynamometer test), sensory (Von Frey test), and olfactory (peppermint oil test) ability. The Mini-Mental Status Exam was administered to determine level of dementia; medical and laboratory data were collected. Results:Sensory and olfactory deficits lateralized to the left side of the body, while motor deficits lateralized to the right side. We found clinical correlates of motor lateralization: female, depression, MMSE <15, and diabetes. While clinical correlates of sensory lateralization: use of psychotherapeutic agent, age ≥85, MMSE <15, and male. Lastly, clinical correlates of olfactory lateralization: age <85, number of medications >10, and male. Conclusion:These lateralized deficits in body function can act as early clinical markers for improved diagnosis and treatment. Future research should identify correlates and corresponding therapies to strengthen at-risk areas.

中文翻译:

痴呆症中运动、感觉和嗅觉领域的侧化缺陷

背景:痴呆患者的运动、感觉和嗅觉能力存在功能缺陷。这些缺陷的测量已被讨论为潜在的临床标志物。目的:我们测量了身体左侧和右侧的运动、感觉和嗅觉功能的缺陷,以研究潜在的身体偏侧化。方法:这项 IRB 批准的研究 (N = 84) 对粗大运动(测功机测试)、感觉(Von Frey 测试)和嗅觉(薄荷油测试)能力进行了左/右临床测试。进行简易精神状态检查以确定痴呆程度;收集了医学和实验室数据。结果:感觉和嗅觉障碍向身体左侧偏侧,而运动障碍向右侧偏侧。我们发现了运动偏侧化的临床相关性:女性、抑郁、MMSE <15、和糖尿病。感觉偏侧化的临床相关性:使用心理治疗剂、年龄≥85、MMSE <15 和男性。最后,嗅觉偏侧化的临床相关性:年龄<85,药物数量>10,男性。结论:这些身体功能的侧化缺陷可以作为改善诊断和治疗的早期临床标志物。未来的研究应确定相关因素和相应的治疗方法,以加强高危区域。
更新日期:2021-01-12
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