The association between the presence of anti-interferon-γ autoantibodies and the onset of immunodeficiency with intracellular infections has been clearly established. No standard regimen to control the production of these pathogenic autoantibodies, apart from antimicrobial therapy to eliminate infections, contributes to the medical burden of this syndrome, which sometimes has a fatal outcome. In this review, we summarize the findings on anti-interferon-γ autoantibodies to facilitate further research and to provide guidance for treatment strategies.

中文翻译：

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Minireview：抗干扰素-γ自身抗体的见解

已经清楚地确定了抗干扰素-γ自身抗体的存在与免疫缺陷的发生与细胞内感染之间的关联。除了用于消除感染的抗微生物治疗外，没有标准的方案来控制这些致病性自身抗体的产生，这会增加这种综合征的医疗负担，有时会导致致命的后果。在这篇综述中，我们总结了抗干扰素-γ自身抗体的发现，以促进进一步的研究并为治疗策略提供指导。