Working memory (WM) deficits are pervasive co-morbidities of epilepsy. Although the pathophysiological mechanisms underpinning these impairments remain elusive, it is thought that WM depends on oscillatory interactions within and between nodes of large-scale functional networks. These include the hippocampus and default mode network as well as the prefrontal cortex and frontoparietal central executive network. Here, we review the functional roles of neural oscillations in subserving WM and the putative mechanisms by which epilepsy disrupts normative activity, leading to aberrant oscillatory signatures. We highlight the particular role of interictal epileptic activity, including interictal epileptiform discharges and high frequency oscillations (HFOs) in WM deficits. We also discuss the translational opportunities presented by greater understanding of the oscillatory basis of WM function and dysfunction in epilepsy, including potential targets for neuromodulation.

中文翻译：

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癫痫工作记忆功能和功能障碍的振荡基础

工作记忆 (WM) 缺陷是癫痫的普遍并发症。尽管支撑这些损伤的病理生理机制仍然难以捉摸，但人们认为 WM 依赖于大规模功能网络节点内部和节点之间的振荡相互作用。这些包括海马体和默认模式网络以及前额叶皮层和额顶中枢执行网络。在这里，我们回顾了神经振荡在支持 WM 中的功能作用以及癫痫扰乱规范活动、导致异常振荡特征的假定机制。我们强调了发作间期癫痫活动的特殊作用，包括发作间期癫痫样放电和高频振荡 (HFO) 在 WM 缺陷中。