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Graphene-Modified Titanium Surface Enhances Local Growth Factor Adsorption and Promotes Osteogenic Differentiation of Bone Marrow Stromal Cells
Frontiers in Bioengineering and Biotechnology ( IF 5.7 ) Pub Date : 2021-01-12 , DOI: 10.3389/fbioe.2020.621788
Jiayu Lu , Jiayue Sun , Derong Zou , Jinlin Song , Sheng Yang

Graphene coating exhibits excellent abilities of protein adsorption and cell adhesion, which might expand the osteogenic activity of titanium implant surface to adapt to the environment of low bone mass and poor bone quality. In this paper, we designed and explored the graphene-coated titanium sheet, through the surface modification of oxygen-containing functional groups, to optimize the adsorption capacity of material by improving the electrostatic interactions, and successfully adsorbed and sustained-released a variety of osteogenic related growth factors in the autologous concentrated growth factors. Compared with the pure titanium, we observed that the bone marrow stromal cells (BMSCs) on the graphene-coated titanium with concentrated growth factors showed a flat shape and expressed osteogenic related genes and proteins, while the coating surfaces promoted and accelerated the osteogenic differentiation ability of BMSCs. The results suggested that it might be a feasible alternative to improve the osteogenesis of dental implant in the early stage.

中文翻译:

石墨烯修饰钛表面增强局部生长因子吸附并促进骨髓基质细胞的成骨分化

石墨烯涂层表现出优异的蛋白质吸附和细胞粘附能力,可能会扩大钛种植体表面的成骨活性,以适应低骨量和骨质量差的环境。在本文中,我们设计并探索了石墨烯包覆的钛片,通过含氧官能团的表面改性,通过改善静电相互作用来优化材料的吸附能力,并成功吸附和缓释多种成骨物质。相关生长因子在自体浓缩生长因子中。与纯钛相比,我们观察到生长因子浓缩的石墨烯涂层钛上的骨髓基质细胞(BMSCs)呈扁平状,并表达成骨相关基因和蛋白质,而涂层表面促进和加速了 BMSCs 的成骨分化能力。结果表明,在早期改善牙种植体的成骨可能是一种可行的替代方法。
更新日期:2021-01-12
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