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Ultra-Small Iron Nanoparticles Target Mitochondria Inducing Autophagy, Acting on Mitochondrial DNA and Reducing Respiration
Pharmaceutics ( IF 5.4 ) Pub Date : 2021-01-12 , DOI: 10.3390/pharmaceutics13010090
Lorenzo Rivas-García , José Luis Quiles , Alfonso Varela-López , Francesca Giampieri , Maurizio Battino , Jörg Bettmer , María Montes-Bayón , Juan Llopis , Cristina Sánchez-González

The application of metallic nanoparticles (materials with size at least in one dimension ranging from 1 to 100 nm) as a new therapeutic tool will improve the diagnosis and treatment of diseases. The mitochondria could be a therapeutic target to treat pathologies whose origin lies in mitochondrial dysfunctions or whose progression is dependent on mitochondrial function. We aimed to study the subcellular distribution of 2–4 nm iron nanoparticles and its effect on mitochondrial DNA (mtDNA), mitochondrial function, and autophagy in colorectal cell lines (HT-29). Results showed that when cells were exposed to ultra-small iron nanoparticles, their subcellular fate was mainly mitochondria, affecting its respiratory and glycolytic parameters, inducing the migration of the cellular state towards quiescence, and promoting and triggering the autophagic process. These effects support the potential use of nanoparticles as therapeutic agents using mitochondria as a target for cancer and other treatments for mitochondria-dependent pathologies.

中文翻译:

超小铁纳米颗粒靶向线粒体诱导自噬,作用于线粒体DNA并减少呼吸

金属纳米颗粒(尺寸至少在一个维度上介于1到100 nm之间的材料)作为一种新的治疗工具的应用将改善疾病的诊断和治疗。线粒体可能是治疗起源于线粒体功能障碍或其进展取决于线粒体功能的病理学的治疗靶标。我们旨在研究2–4 nm铁纳米颗粒的亚细胞分布及其对结肠直肠癌细胞系(HT-29)中线粒体DNA(mtDNA),线粒体功能和自噬的影响。结果显示,当细胞暴露于超小型铁纳米颗粒时,其亚细胞命运主要是线粒体,影响其呼吸和糖酵解参数,从而诱导细胞态向静止状态迁移,促进和触发自噬过程。这些作用支持使用纳米粒作为治疗剂,将线粒体用作癌症的靶标,并用于线粒体依赖性病理的其他治疗。
更新日期:2021-01-12
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