ABSTRACT

The purpose of this review was to search for articles on human studies investigating the relationship between melatonin and high-risk pregnancy. An electronic search was conducted in the MEDLINE and PubMed databases from September 2010 to October 2020. The initial search produced 441 articles in PubMed and 407 in MEDLINE. After sorting the titles and abstracts, and removing duplicates, we had nine articles in PubMed and three in Medline. The results of these studies mainly show that the association between melatonin receptor 1B polymorphisms and gestational diabetes mellitus is the most common physiological mechanism relating to melatonin and high-risk pregnancy in this review. In addition, the circadian rhythm, decreased melatonin production, and anti-inflammatory and antioxidant effects were explored. The findings of our review of the literature suggest that this indoleamine is essential in high-risk pregnancy for its potent anti-inflammatory and antioxidant effects, regulation of the circadian rhythm, and genic receptor expression.

摘要

这篇综述的目的是搜索有关褪黑素与高危妊娠之间关系的人体研究文章。从2010年9月至2020年10月在MEDLINE和PubMed数据库中进行了电子搜索。最初的搜索在PubMed中产生441篇文章，在MEDLINE中产生407篇文章。在对标题和摘要进行排序并除去重复项之后，我们在PubMed中撰写了9篇文章，在Medline中撰写了3篇文章。这些研究的结果主要表明，褪黑激素受体1B多态性与妊娠糖尿病之间的关联是本研究中与褪黑激素和高危妊娠有关的最常见生理机制。此外，还探讨了昼夜节律，褪黑激素生成减少以及抗炎和抗氧化作用。