An efficient catalyst‐free one‐pot three‐component synthesis of penta‐substituted pyrroles has been successfully developed. A variety of penta‐substituted pyrroles were straightforwardly synthesized from good to excellent yields (78%–93%) by using easily accessible starting materials under mild conditions. This protocol also provided α‐amino ketones in good yields (87%–98%) without column chromatography.

中文翻译：

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高效功能的吡咯和α-氨基酮的无催化剂简便高效合成

成功开发了一种高效的无催化剂的五取代吡咯单锅三组分合成方法。通过在温和条件下使用容易获得的起始原料，可以直接合成多种五取代吡咯，从高产率到优异产率（78％–93％）。该方案还提供了无需柱色谱的高产率（87％–98％）的α-氨基酮。