Protective efficacy of rutin over liver, kidney, and brain dysfunctions was evaluated in this investigation. Rutin (5, 10, and 20 mg/kg) was administered continuously for 6 days followed by single dose of D‐galactosamine (300 mg/kg I.P.) and lipopolysaccharide (50 µg/kg I.P.) on the 6th day. Hematological, serological, biochemical, and histological aspects were considered for this study. One‐way ANOVA (p ≤ .05) followed by Tukey's HSD post hoc test determined the statistical significance. Serum AST, ALT, ALP, urea, uric acid, and creatinine were increased significantly, whereas albumin and glucose were significantly decreased after combined exposure to LPS and D‐GalN. Glutathione level and activity of SOD and catalase were decreased, whereas lipid peroxidation, triglycerides, and cholesterol were increased in tissue samples due to LPS‐ and D‐GalN‐induced toxicity. Prophylactic treatment of rutin maintained studied variables toward control claiming the protective role of rutin.

中文翻译：

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芦丁对脂多糖和D-半乳糖胺诱发的肝，肾和脑功能异常的联合暴露的保护作用：血液学，生化和组织学证据

在这项研究中评估了芦丁对肝，肾和脑功能障碍的保护作用。连续6天连续服用芦丁（5、10和20 mg / kg），然后在第6天单次给药D-半乳糖胺（IP剂量为300 mg / kg）和脂多糖（IP剂量为50 µg / kg）。这项研究考虑了血液学，血清学，生化和组织学方面。单因素方差分析（p  ≤0.05），其次是杜克的HSD事后检验确定统计学意义。与LPS和D-GalN联合暴露后，血清AST，ALT，ALP，尿素，尿酸和肌酐显着升高，而白蛋白和葡萄糖显着降低。由于LPS和D-GalN诱导的毒性，组织样品中的谷胱甘肽水平和SOD和过氧化氢酶活性降低，而脂质过氧化，甘油三酸酯和胆固醇升高。芦丁的预防性治疗保持了对对照的研究变量，声称其具有芦丁的保护作用。